One of the great challenges in drug discovery is rationalizing lead optimization. In this phase, compounds that have been identified as the potential drug candidates need to be modified carefully with appropriate ADMET properties. The key questions faced by medicinal chemists are which compound(s) should be made next and how to balance multiple properties. To avoid the poor or ill-advised decisions, it is crucial to draw credible transformation rules from multiple experimental assays and apply them for efficient optimization. Therefore, OptADMET, the first integrated chemical transformation rule platform covering 32 important ADMET properties, is able to provide multiple-property rules and apply invaluable experience for lead optimization.